Amoxicillin & Clavulanate Potassium Oral Suspension is a drug composition under the RION brand. It is an antibiotic drug that is used to treat a wide variety of bacterial infections in the body. Bacteria can invade the normal cell of the body and infect those cells leading to the infection condition in the body. There is a wide range of infections that can occur in the human body. It depends on the species of bacteria and the infected organ. Amoxicillin & Clavulanate Potassium Oral Suspension inhibits the ability of bacterial cells to form cell walls. The cell wall is an essential component of the bacterial cell and without a cell wall, bacterial l can not survive. PHARMACOKINETICS: • ABSORPTION: Dosing in the fasted or fed state has minimal effect on the pharmacokinetics of amoxicillin. While amoxicillin/clavulanate potassium can be given without regard to meals, absorption of clavulanate potassium when taken with food is greater relative to the fasted state. In one study, the relative bioavailability of clavulanate was reduced when amoxicillin/clavulanate potassium was dosed after eating something. • DISTRIBUTION: Component in amoxicillin/clavulanate potassium is highly protein-bound; clavulanic acid is approximately 25% bound to human serum and amoxicillin is approximately 18% bound. Amoxicillin diffuses readily into most body tissues and fluids with the exception of the brain and spinal fluid. • METABOLISM AND EXCRETION: The half-life of amoxicillin after the oral administration of amoxicillin/clavulanate potassium is 1.3 hours and that of clavulanic acid is 1 hour. Approximately 50% to 70% of the amoxicillin and approximately 25% to 40% of the clavulanic acid are excreted unchanged in urine during the first 6 hours after administration of a single 250 mg/125 mg or 500 mg/125 mg tablet of amoxicillin/clavulanate potassium. INDICATIONS: Amoxicillin/clavulanic acid is a penicillin-type antibiotic used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria. This antibiotic only treats bacterial infections. It will not work for viral infections (e.g., common cold, flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness. Uses of Amoxicillin & Clavulanate Potassium Oral Suspension It is used in the treatment of bacterial infections. Bacterial infections can cause a wide range of diseases in the body. This medication is beneficial in curing: Tuberculosis Cough Chronic wet cough Throat infection Bronchitis Pneumonia Urinary Tract Infections Directions of use Amoxicillin & Clavulanate Potassium should not be taken without the prescription of a Doctor. The suspension should be shaken well before use and taken before meals. 12 hours of gap is advised between the two doses. Side effects of Amoxicillin & Clavulanate Potassium Oral Suspension Stomach Pain Dark Urine Vomiting Diarrhea Nausea Precautions Consult a doctor before taking this medication and discuss these conditions regarding health history: Allergies Liver disease Addiction Breastfeeding Pregnancy Kidney disease Vaccinations Drinking Smoking
